Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease

Frontiers in Pharmacology

Wei-Jen Cheng¹  Michal Korinek³  Tsong-Long Hwang⁴  Chih-Chao Chiang⁷ 

[1]Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

[2]Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

[3]Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan

[4]Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan

[5]Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan

[6]Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan

[7]Puxin Fengze Chinese Medicine Clinic, Taoyuan, Taiwan

[8]Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan, Taiwan

[9]School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan

关键词: coronavirus disease 2019;    severe acute respiratory syndrome coronavirus 2;    acute respiratory distress syndrome;    neutrophils;    neutrophil extracellular trap;   

DOI  :  10.3389/fphar.2020.572009

来源: DOAJ

【 摘 要 】

This review describes targeting neutrophils as a potential therapeutic strategy for acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID-19), a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutrophil counts are significantly elevated in patients with COVID-19 and significantly correlated with disease severity. The neutrophil-to-lymphocyte ratio can serve as a clinical marker for predicting fatal complications related to ARDS in patients with COVID-19. Neutrophil-associated inflammation plays a critical pathogenic role in ARDS. The effector functions of neutrophils, acting as respiratory burst oxidants, granule proteases, and neutrophil extracellular traps, are linked to the pathogenesis of ARDS. Hence, neutrophils can not only be used as pathogenic markers but also as candidate drug targets for COVID-19 associated ARDS.

【 授权许可】

Unknown