Regulatory Role of Peritoneal B Cells in EAE

Serbian Journal of Experimental and Clinical Research

Milovanović Jelena¹  Stojanović Bojana¹  Arsenijević Aleksandar¹  Lukic Miodrag L.²  Milovanovic Marija³ 

[1] Centar za molekulsku medicinu i istraživanje matičnih ćelija, Fakultet medicinskih nauka, Univerzitet u Kragujevcu, Kragujevac, Srbija;Center for Molecular Medicine and Stem Cell Research, Faculty of Medicine University of Kragujevac, Kragujevac, Serbia;Center for Molecular Medicine and Stem Cell Research,Faculty of Medicine University of Kragujevac Svetozara Markovica 69, 34000 Kragujevac, Serbia;

关键词: multiple sclerosis;    eae;    b cells;    peritoneal regulatory b cells;   

DOI  :  10.1515/sjecr-2015-0048

来源: DOAJ

【 摘 要 】

B cells play a dual role in the pathogenesis of autoimmune diseases. In experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, B cells contribute to disease progression, while their regulatory role predominates in the initial phases of disease development. Several studies have identified different subsets of regulatory B cells, mostly in the spleen, which are all sources of IL-10. However, peritoneal regulatory B cells are also important producers of IL-10, can migrate towards inflammatory stimuli, and could have an immunoregulatory function. As we have observed expansion of regulatory B cells in the peritoneum of resistant mice after EAE induction, herein we discuss the regulatory roles of B cells in EAE pathogenesis and the possible role of peritoneal regulatory B cells in resistance to EAE induction.

【 授权许可】

Unknown