Effect of DMPA on IL-1 Alpha in Serum of Women with Endometrioma

Thai Journal of Obstetrics and Gynaecology

Matchuporn Sukprasert¹  Worawun Lupthaluk¹  Sawaek Weerakiet¹  Supatra Leelaphiwat²  Sasivimol Rattanasiri³ 

[1] Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand;Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand;Research center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand;

关键词: endometriosis;    endometrioma;    conservative surgery;    IL-1α;    DMPA;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective:To study the effect of DMPA on serum IL-1α in women with endometrioma undergoing the conservative surgery.Materials and methods:Arandomizedclinicaltrialwasperformedinthirty-fivewomenwithendometriomawhounderwentconservativesurgeryinReproductiveEndocrinologyandLaparoscopy clinic in Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital. These patients were randomly assigned to one of the following treatments: group A surgery and postoperative treatment with DMPA 150 mg intramuscular or group B surgery alone.SerumIL-1αlevelwasmeasuredbyenzyme-linkedimmunosorbentassay(ELISA)inbothgroups. Pain scores were evaluated using a visual analog scale (VAS) at 2 and 12 weeks after the operation.Results:There was no significant difference in IL-1α serum levels between both groups at 2 weeks and 12 weeks after the surgery (p = 0.06 and 0.86 respectively). There was no significant differenceinpreandpostoperativeIL-1αlevelbetweenbothgroup(p=0.23and1.00respectively).Pain scores of both groups were significantly decreased at 2 weeks and 12 weeks after the surgery (p < 0.001).The patients in DMPA group had significantly less pain scores at 12 weeks after the surgery (p = 0.01). Conclusion:ThecurrentstudydemonstratedthatnosignificantchangeofIL-1αserumlevelinwomen with endometrioma before and after the surgery, with or without postoperative treatment with DMPA. We found decreasing of pain score in both group after surgery and less pain score in DMPA group.

【 授权许可】

Unknown