Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach

International Journal of Molecular Sciences

Milica Bozic¹  Alicia Llorente¹  Sofija Glamočlija²  Maja Kosanović²  JoséM. Valdivielso³ 

[1]Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, Norway

[2]Institute for the Application of Nuclear Energy, INEP, University of Belgrade, 11080 Belgrade, Serbia

[3]Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen RETIC, 25196 Lleida, Spain

关键词: extracellular vesicles;    exosomes;    cellular communication;    renal fibrosis;    CKD;    therapeutic agents;   

DOI  :  10.3390/ijms22083887

来源: DOAJ

【 摘 要 】

Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight advantages and future perspectives of the therapeutic applications of EVs in renal diseases.

【 授权许可】

Unknown