Disruptions in neural connectivity associated with reduced susceptibility to a depth inversion illusion in youth at ultra high risk for psychosis

NeuroImage: Clinical

Thomas V. Papathomas¹  Raeana E. Newberry²  Derek J. Dean²  Andrea Pelletier-Baldelli²  Tina Gupta³  Ivanka Ristanovic³  Vijay A. Mittal³  Jessica A. Bernard⁴  Brian P. Keane⁵  Steven M. Silverstein⁵ 

[1] Center for Cognitive Science, Rutgers, The State University of New Jersey, United States;Department of Psychology and Neuroscience, University of Colorado, United States;Department of Psychology, Northwestern University, United States;Department of Psychology, Texas A&M University, United States;University Behavioral Health Care, Department of Psychiatry, Rutgers, The State University of New Jersey, United States;

关键词: Depth inversion illusion;    Hollow-mask illusion;    Top-down processing;    Bottom-up processing;    UHR;    fcMRI;   

DOI  :  10.1016/j.nicl.2016.09.022

来源: DOAJ

【 摘 要 】

Patients with psychosis exhibit a reduced susceptibility to depth inversion illusions (DII) in which a physically concave surface is perceived as convex (e.g., the hollow mask illusion). Here, we examined the extent to which lessened susceptibility to DII characterized youth at ultra high risk (UHR) for psychosis. In this study, 44 UHR participants and 29 healthy controls judged the apparent convexity of face-like human masks, two of which were concave and the other convex. One of the concave masks was painted with realistic texture to enhance the illusion; the other was shown without such texture. Networks involved with top-down and bottom-up processing were evaluated with resting state functional connectivity magnetic resonance imaging (fcMRI). We examined regions associated with the fronto-parietal network and the visual system and their relations with susceptibility to DII. Consistent with prior studies, the UHR group was less susceptible to DII (i.e., they were characterized by more veridical perception of the stimuli) than the healthy control group. Veridical responses were related to weaker connectivity within the fronto-parietal network, and this relationship was stronger in the UHR group, suggesting possible abnormalities of top-down modulation of sensory signals. This could serve as a vulnerability marker and a further clue to the pathogenesis of psychosis.

【 授权许可】

Unknown