Basidiobolomycosis in Togo: clinico-pathological study of a series of 12 presumed cases

BMC Research Notes

Abas Mouhari-Toure¹  Bayaki Saka²  Palokinam Pitché²  Toukilnan Djiwa³  Tchin Darré³  Gado Napo-Koura³ 

[1]Department of Dermatology, University Teaching Hospital of Kara

[2]Department of Dermatology, University Teaching Hospital of Lomé

[3]Department of Pathology, University Teaching Hospital of Lomé

关键词: Basidiobolomycosis;    Basidiobolus ranarum;    Histology;    Togo;    Sub-Saharan Africa;   

DOI  :  10.1186/s13104-018-3777-8

来源: DOAJ

【 摘 要 】

Abstract Objective The purpose of our study was to describe the histological diagnosed of the Basidiobolomycosis cases from 1990 to 2017 (28 years) in the only Pathology Anatomy Laboratory in Togo. Results A total of 12 cases of suspected Basidiobolomycosis have been identified. The sex ratio (M/F) was 2. The average age of the patients was 24.8 ± 1.6 years. Six patients (6/12) had a pathological history: HIV infection (n = 4 cases) and tuberculosis (n = 2 cases). The clinical manifestations were localized to pure skin (n = 9 cases), skin and mucous digestive (n = 2 cases) and disseminated (n = 1 cases). Direct mycological examination and culture in 4 patients was positive in 3 patients. The samples examined consisted of 11 cutaneous biopsies measuring 1–3 cm and a biopsy of the intestinal mucosa. Histology showed granulomatous inflammation of the dermohypodermal site with numerous giant cells associated with eosinophilic polynuclear cells, in which there are 5–7 mm non-septate, irregular mycelial filaments. Patients were treated with ketoconazole at a dose of 10 mg/kg daily. The progression of the patients’ condition was favorable after 4 weeks of treatment with a regression of the closets size. Patients were completely healed after 8 weeks of treatment, without recurrence after 6 months. No deaths have been recorded.

【 授权许可】

Unknown