The Roles of Histone Demethylase Jmjd3 in Osteoblast Differentiation and Apoptosis

Journal of Clinical Medicine

Lihong Qiu¹  Haiyan Sun¹  Di Yang¹  Bo Yu¹ 

[1] Department of Endodontics, School of Stomatology, China Medical University, Shenyang 110002, China;

关键词: Jmjd3;    H3K27me3;    osteoblast differentiation;    bone formation;    osteoblast apoptosis;   

DOI  :  10.3390/jcm6030024

来源: DOAJ

【 摘 要 】

Posttranslational modifications including histone methylation regulate gene transcription through directly affecting the structure of chromatin. Trimethylation of histone 3 lysine 27 (H3K27me3) is observed at the promoters of a wide variety of important genes, especially for mammalian development, and contributes to gene silencing. Demethylase Jumonji domain-containing 3 (Jmjd3) catalyzes the transition of H3K27me3 to H3K27me1, therefore from a repressive to an active status of gene expression. Jmjd3 plays important roles in cell differentiation, inflammation, and tumorigenesis by targeting distinct transcription factors. In this review, we summarize the pivotal roles of Jmjd3 in maintaining skeletal homeostasis through regulating osteoblast differentiation, maturation, and apoptosis.

【 授权许可】

Unknown