Protective, Antioxidant and Antiproliferative Activity of Grapefruit IntegroPectin on SH-SY5Y Cells

International Journal of Molecular Sciences

Miriana Scordino¹  Valentina Di Liberto¹  Costanza Giardina¹  Giuseppa Mudò¹  Stefania Raimondo²  Alessandro Attanzio³  Francesco Meneguzzo⁴  Domenico Nuzzo⁵  Pasquale Picone⁵  Mario Pagliaro⁶  Francesco Giordano⁶  Rosaria Ciriminna⁶  Antonino Scurria⁶ 

[1] Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università di Palermo, Corso Tukory 129, 90134 Palermo, Italy;Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università di Palermo, Via Divisi 83, 90133 Palermo, Italy;Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy;Istituto per la Bioeconomia, CNR, via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy;Istituto per la Ricerca e l’Innovazione Biomedica, CNR, via U. La Malfa 153, 90146 Palermo, Italy;Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy;

关键词: pectin;    cell cycle;    hydrodynamic cavitation;    oxidative stress;    mitochondria;    neurological disease;   

DOI  :  10.3390/ijms22179368

来源: DOAJ

【 摘 要 】

Tested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful protective, antioxidant and antiproliferative agent. The strong antioxidant properties of this new citrus pectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make it an attractive therapeutic and preventive agent for the treatment of oxidative stress-associated brain disorders. Similarly, the ability of this pectic polymer rich in RG-I regions, as well as in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface, to inhibit cell proliferation or even kill, at high doses, neoplastic cells may have opened up new therapeutic strategies in cancer research. In order to take full advantage of its vast therapeutic and preventive potential, detailed studies of the molecular mechanism involved in the antiproliferative and neuroprotective of this IntegroPectin are urgently needed.

【 授权许可】

Unknown