Diagnostic Accuracy of Different Soluble fms-Like Tyrosine Kinase 1 and Placental Growth Factor Cut-Off Values in the Assessment of Preterm and Term Preeclampsia: A Gestational Age Matched Case-Control Study

Frontiers in Medicine

Begona Martinez de Tejada¹  Soeren Lange²  Andrea Kreienbühl³  Evelyn A. Huhn³  Irene Hoesli³  Ina Hoffmann³  Andreas Schoetzau³  Olav Lapaire³  Martin Hund⁴ 

[1] Department of Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland;Department of Obstetrics and Gynecology, Institutions Hospital du Nord Vaudois, Yverdon-les-Bains, Switzerland;Department of Obstetrics and Gynecology, University Hospital Basel, Basel, Switzerland;Roche Diagnostics International, Rotkreuz, Switzerland;

关键词: preeclampsia;    hypertension in pregnancy;    diagnosis;    biomarker;    sFlt-1;    PlGF;   

DOI  :  10.3389/fmed.2018.00325

来源: DOAJ

【 摘 要 】

Introduction: The objective was to investigate the diagnostic accuracy of different thresholds of the soluble vascular endothelial growth factor receptor-1 (sFlt-1) and the placental growth factor (PlGF) in preterm (≤37 weeks) and term (>37 weeks) preeclampsia (PE).Materials and Methods: A nested case-control study was performed from a high-risk Swiss cohort. Only blood samples on the day of PE diagnosis were included. The primary outcome was to verify the diagnosis using the recently proposed cut-off values for PE (sFlt-1:PlGF ratio of ≥85 in ≤ 34 weeks or ≥110 in >34 weeks), and the gestational age dependent centiles.Results: Thirty-four women with preterm PE were matched with 64 controls and 25 women with term PE with 45 controls. The test performance of the sFlt-1:PlGF ratio in preterm PE was very good (AUROCC of 0.95). The sFlt-1:PlGF ratio could adequately predict adverse fetal or neonatal outcome. In term PE, sFlt-1 alone showed a slightly better diagnostic accuracy with an AUROCC of 0.84. Almost all women with a sFlt-1:PlGF ratio above threshold delivered during the following week.Discussion: In pregnant women with high risk of developing PE, the sFlt-1:PlGF ratio and sFlt-1 levels help clinicians to confirm the diagnosis of imminent preterm PE and can additionally be used to rule out PE at term.

【 授权许可】

Unknown