Allergen specific immunotherapy induced multi-organ failure

The Pan African Medical Journal

Chaker Ben Salem¹  Sehli Jihed²  Ben Saida Imene²  Boussarsar Mohamed²  Aissa Sana²  Azouzi Abdelbeki²  Khedher Ahmed² 

[1] Department of Clinical Pharmacology. Faculty of Medicine of Sousse, Tunisia;Intensive Care Unit. Farhat Hached Hospital, Sousse, Tunisia;

关键词: allergen specific immunotherapy;    multi-organ failure;    allergy;    drug reaction;    desensitization;   

DOI  :  10.11604/pamj.2013.14.155.1891

来源: DOAJ

【 摘 要 】

Allergen specific immunotherapy (ASI) is a well-documented treatment for allergic asthma, rhinitis and allergy to bee venoms. Immunotherapy with subcutaneous injections of allergens extracts has proved beneficial in reducing symptoms of allergic rhinitis and asthma. Side effects due to specific immunotherapy in short term have been largely documented. These effects were various but were usually mild. Fatal reactions are less frequent. We reported a case of a woman, with a history of allergic asthma under specific desensitization protocol who developed an acute multi-organ failure (MOF) consecutive to administration of ASI (Alustal Stallergenes SA, France). This fatal reaction has never been described as adverse event of specific immunotherapy. We aimed to describe this dramatic reaction, expose the arguments to define the relationship between the administration of allergen extract and the occurrence of this fatal reaction.

【 授权许可】

Unknown