Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

International Journal of Molecular Sciences

Ajaikumar B. Kunnumakkara¹  Ganesan Padmavathi¹  Nand Kishor Roy¹  Kishore Banik¹  Alan Prem Kumar²  Gautam Sethi³  Lu Fan⁴  Abhishek Manoj Ranaware⁵  Vishwas Deshpande⁵ 

[1] Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India;Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore;Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam;Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore;Department of Zoology, Yashwantrao Chavan Institute of Science, Satara, Maharashtra 415001, India;

关键词: magnolol;    cancer;    phytochemicals;    molecular targets;    chemoresistance;   

DOI  :  10.3390/ijms19082362

来源: DOAJ

【 摘 要 】

The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

【 授权许可】

Unknown