Recombinant Proteins-Based Strategies in Bone Tissue Engineering

Biomolecules

Pedro Esbrit¹  José Carlos Rodriguez-Cabello²  Matilde Alonso²  Marina Paulini³  João Paulo Mardegan Issa³  Iván Nadir Camal Ruggieri⁴  Melina Ramallo⁴  Sara Feldman⁴ 

[1] Area Osteoarticular, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, 28040 Madrid, Spain;BIOFORGE, Group for Advanced Materials and Nanobiotechnology, CIBER-BBN, University of Valladolid, 47011 Valladolid, Spain;Faculdade de Odontologia de Ribeirao Preto, University of Sao Paulo, Sao Paulo 05508-060, Brazil;LABOATEM, Biology and Tissue Engineering Laboratory, School of Medicine, National Rosario University, Rosario 2011, Argentina;

关键词: recombinant proteins;    bone;    tissue engineering;    BMP-2;    scaffold;   

DOI  :  10.3390/biom12010003

来源: DOAJ

【 摘 要 】

The increase in fracture rates and/or problems associated with missing bones due to accidents or various pathologies generates socio-health problems with a very high impact. Tissue engineering aims to offer some kind of strategy to promote the repair of damaged tissue or its restoration as close as possible to the original tissue. Among the alternatives proposed by this specialty, the development of scaffolds obtained from recombinant proteins is of special importance. Furthermore, science and technology have advanced to obtain recombinant chimera’s proteins. This review aims to offer a synthetic description of the latest and most outstanding advances made with these types of scaffolds, particularly emphasizing the main recombinant proteins that can be used to construct scaffolds in their own right, i.e., not only to impregnate them, but also to make scaffolds from their complex structure, with the purpose of being considered in bone regenerative medicine in the near future.

【 授权许可】

Unknown