Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection

Microbial Cell

Romeu Viana¹  Diana Pereira¹  Mónica Galocha¹  Mafalda Cavalheiro¹  Pedro Pais¹  Miguel Cacho Teixeira¹ 

[1] Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.;

关键词: fungal pathogens;    host-pathogen interaction;    microevolution;    virulence;    biofilm formation;    antifungal resistance;   

DOI  :  10.15698/mic2019.03.670

来源: DOAJ

【 摘 要 】

Infections by the pathogenic yeasts Candida albicans and Candida glabrata are among the most common fungal diseases. The success of these species as human pathogens is contingent on their ability to resist antifungal therapy and thrive within the human host. C. glabrata is especially resilient to azole antifungal treatment, while C. albicans is best known for its wide array of virulence features. The core mechanisms that underlie antifungal resistance and virulence in these pathogens has been continuously addressed, but the investigation on how such mechanisms evolve according to each environment is scarcer. This review aims to explore current knowledge on microevolution experiments to several treatment and host-associated conditions in C. albicans and C. glabrata. The analysis of adaptation strategies that evolve over time will allow to better understand the mechanisms by which Candida species are able to achieve stable phenotypes in real-life scenarios, which are the ones that should constitute the most interesting drug targets.

【 授权许可】

Unknown