Tango of dual nanoparticles: Interplays between exosomes and nanomedicine

Bioengineering & Translational Medicine

Jiaqi Xiao¹  Bing Yan²  Yi Zhang³  Qiu Zhang⁴  Fangong Kong⁵  Yabin Wang⁵  Wenzhen Wang⁶ 

[1] Advanced Research Institute for Multidisciplinary Science Qilu University of Technology, Shandong Academy of Science Jinan China;Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education Guangzhou University Guangzhou China;Rutgers Cancer Institute of New Jersey Rutgers State University of New Jersey New Brunswick New Jersey USA;School of Environmental Science and Engineering Shandong University Qingdao China;State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology, Shandong Academy of Science Jinan China;The Secondary Hospital, Cheeloo College of Medicine Shandong University Jinan China;

关键词: exosome;    nanomedicine;    nanoparticle;    targeted drug delivery;   

DOI  :  10.1002/btm2.10269

来源: DOAJ

【 摘 要 】

Abstract Exosomes are lipid bilayer vesicles released from cells as a mechanism of intracellular communication. Containing information molecules of their parental cells and inclining to fuse with targeted cells, exosomes are valuable in disease diagnosis and drug delivery. The realization of their clinic applications still faces difficulties, such as lacking technologies for fast purification and functional reading. The advancement of nanotechnology in recent decades makes it promising to overcome these difficulties. In this article, we summarized recent progress in utilizing the physiochemical properties of nanoparticles (NPs) to enhance exosome purification and detection sensitivity or to derive novel technologies. We also discussed the valuable applications of exosomes in NPs‐based drug delivery. Till now most studies in these fields are still at the laboratory research stage. Translation of these bench works into clinic applications still has a long way to go.

【 授权许可】

Unknown