Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles

Molecules

Wen Luo¹  Yanwu Li¹  Jianyong Yuan¹  Xuetong Wang¹  Suqin Shang¹  Dan Li¹  Ying Zhang¹  Zeshu Dai¹  Zhiyao Li¹  Qingqiang Tian¹ 

[1] Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China;

关键词: imidazolium chloride;    amino protection;    michael addition reaction;    amino deprotection;    solvent-free;    seven-membered ring;   

DOI  :  10.3390/molecules24234224

来源: DOAJ

【 摘 要 】

An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.

【 授权许可】

Unknown