Voriconazole- induced severe hypokalemic rhabdomyolysis: A case report

International Journal of Pediatrics and Adolescent Medicine

Abdullah Algarni, MD¹  Motasem Abuelreish, MD²  Abdulsalam Alawfi, MD³  Jocelyn Donesa, MD³ 

[1] Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia;Department of Pediatrics, Division of Pediatric Infectious Diseases, Taif Children Hospital, Saudi Arabia;Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Saudi Arabia;

关键词: Voriconazole;    Rhabdomyolysis;    Hypokalemia;    Adverse events;   

DOI  :  

来源: DOAJ

【 摘 要 】

We report a child who presented with lower limb weakness and inability to walk, laboratory confirmed severe hypokalemia with typical electrocardiogram changes, and evidence of rhabdomyolysis while on voriconazole treatment for Pseudallescheria boydii soft tissue infection. Although voriconazole is a well-tolerated antifungal agent, hypokalemia is a well-known, yet uncommon side effect associated with its use. Furthermore, hypokalemic-rhabdomyolysis has not been reported with voriconazole use alone. Maintaining the clinical suspicion about the potential association between voriconazole and hypokalemic-rhabdomyolysis can lead to prompt recognition and intervention.

【 授权许可】

Unknown