期刊论文详细信息
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Repeated Administrations of Cardiac Progenitor Cells Are Superior to a Single Administration of an Equivalent Cumulative Dose
Qinghui Ou1  Roberto Bolli1  Xian‐Liang Tang1  Anna M. Gumpert1  Heather Stowers1  Marcin Wysoczynski1  Greg Hunt1  Qianhong Li1  Wen‐Jian Wu1  Shunichi Nakamura1 
[1] Division of Cardiovascular Medicine and Institute of Molecular Cardiology, University of Louisville, KY;
关键词: cardiac function;    cardiac progenitor cells;    cell transplantation;    ischemic cardiomyopathy;    myocardial infarction;    repeated doses;   
DOI  :  10.1161/JAHA.117.007400
来源: DOAJ
【 摘 要 】

BackgroundWe have recently found that 3 repeated doses (12×106 each) of c‐kitPOS cardiac progenitor cells (CPCs) were markedly more effective than a single dose of 12×106 cells in alleviating postinfarction left ventricular dysfunction and remodeling. However, since the single‐dose group received only one third of the total number of CPCs given to the multiple‐dose group, it is unknown whether the superior therapeutic efficacy was caused by repeated treatments per se or by administration of a higher total number of CPCs. This issue has major clinical implications because multiple cell injections in patients pose significant challenges, which would be obviated by using 1 large injection. Accordingly, we determined whether the beneficial effects of 3 repeated CPC doses can be recapitulated by 1 large dose containing the same total number of cells. Methods and ResultsRats with a 30‐day‐old myocardial infarction received 3 echo‐guided intraventricular infusions, 35 days apart, of vehicle‐vehicle‐vehicle, 36×106 CPCs‐vehicle‐vehicle, or 3 equal doses of 12×106 CPCs. Infusion of a single, large dose of CPCs (36×106 cells) produced an initial improvement in left ventricular function, but no further improvement was observed after the second and third infusions (both vehicle). In contrast, each of the 3 doses of CPCs (12×106) caused a progressive improvement in left ventricular function, the cumulative magnitude of which was greater than with a single dose. Unlike the single dose, repeated doses reduced collagen content and immune cell infiltration. ConclusionsThree repeated doses of CPCs are superior to 1 dose even though the total number of cells infused is the same, possibly because of greater antifibrotic and anti‐inflammatory actions.

【 授权许可】

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