Metabolic Modulation of Macrophage Function Post Myocardial Infarction

Frontiers in Physiology

Xiaojing Liu¹  Dennis Ding-Hwa Wang²  Mingyue Zhao³  Rong Tian⁴ 

[1] Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China;Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, United States;Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China;Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, United States;

关键词: myocardial infarction;    mitochondrial function;    immunometabolism;    macrophage;    monocyte;   

DOI  :  10.3389/fphys.2020.00674

来源: DOAJ

【 摘 要 】

Macrophages are key components of innate immunity, and they play critical roles in heart health and diseases. Following acute myocardial infarction (MI), infiltrating macrophages undergo drastic phenotypic transition from pro-inflammatory in the early stage to pro-healing in the late stage. Transcriptome analyses of macrophage in the infarct zone show a time-dependent reprogramming of mitochondrial and metabolic functions, which parallels the changes of macrophage function. These observations suggest that mitochondrial and metabolic targets could be exploited for therapeutic opportunities. In this article, we reviewed the recent work on immunometabolic features of macrophage over the MI time continuum. In addition, we summarized currently proposed mitochondrial pathways involved in the functional polarization of macrophage and discussed their potential relevance to the outcome of MI. We expect that these findings will stimulate further investigations in metabolic modulation of innate immunity in the post-MI setting, which could ultimately lead to new strategies for therapy.

【 授权许可】

Unknown