Possible abscopal effect after discontinuation of nivolumab in metastatic renal cell carcinoma

IJU Case Reports

Tatsuya Otaki¹  Masayoshi Kawakami¹  Masanori Hasegawa¹  Masahiro Nitta¹  Yuki Shimizu¹  Yoshiaki Kawamura¹  Takato Uchida¹  Hakushi Kim¹  Nobuyuki Nakajima¹  Akira Miyajima¹  Kentaro Nagao¹  Tatsuo Kano²  Kazuya Oda³ 

[1] Department of Urology Tokai University Graduate School of Medicine Isehara Kanagawa Japan;Department of Urology Tokai University Hachioji Hospital Hachioji Tokyo Japan Japan;vIsehara Kyodo Hospital Isehara Kanagawa Japan;

关键词: abscopal effect;    immune checkpoint inhibitor;    programmed cell death‐1;    radiotherapy;    renal cell carcinoma;   

DOI  :  10.1002/iju5.12195

来源: DOAJ

【 摘 要 】

Introduction Renal cell carcinoma has been considered radioresistant. Recently, several studies have reported the efficacy of combination therapy using radiotherapy and immune checkpoint inhibitors. Case presentation In 1999, a 56‐year‐old woman underwent left nephrectomy (clear cell carcinoma, pT1bN0M0). Seventeen years postoperatively, recurrence in the left lung hilum was observed. Despite administration of three molecular target drugs, all treatments were terminated due to adverse events. Nivolumab was initiated in December 2016. In August 2017, subcutaneous and lung metastases were observed. Moreover in January 2018, right renal metastasis was noted. After 22 cycles of nivolumab treatment, metastasis in the iliac bone was observed, and the patient was subjected to conventional palliative external beam radiation therapy. Five months after radiotherapy, there was significant reduction in multiple metastases. Here, we reported the case presenting with possible abscopal effect. Conclusion Radiotherapy combined with immune checkpoint inhibitors may induce systemic effects against metastatic renal carcinoma.

【 授权许可】

Unknown