Remission of Primary Hyperparathyroidism Following Fine-Needle Aspiration Biopsy: A Case Report and Review of the Literature

AACE Clinical Case Reports

Filomena Cetani, MD, PhD¹  Pierpaolo Falcetta, MD²  Massimo Tonacchera, MD, PhD³ 

[1] Address correspondence and reprint requests to Dr Pierpaolo Falcetta, Department of Clinical and Experimental Medicine, Section of Endocrinology, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy.;Department of Clinical and Experimental Medicine, Section of Endocrinology, University Hospital of Pisa, Pisa, Italy;Endocrinology Unit 2, University Hospital of Pisa, Pisa, Italy;

关键词: primary hyperparathyroidism;    PHPT;    remission;    fine-needle aspiration biopsy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Spontaneous or fine-needle aspiration biopsy (FNAB)-induced remission of primary hyperparathyroidism (PHPT) is an extremely rare and generally transient phenomenon. Methods: A 40-year-old woman with a history of recurrent kidney stones was diagnosed with PHPT (serum calcium, 14.2 mg/dL; parathyroid hormone [PTH], 380 pg/mL). Ultrasonography and scintigraphy findings were consistent with a left enlarged parathyroid. Ultrasound-guided-FNAB cytology of the lesion did not confirm a parathyroid nature. However, levels of PTH within the needle-washing fluid were elevated. Results: After few days, there was evidence of biochemical remission of the hypercalcemia (calcium, 8.1 mg/dL), and at subsequent follow-up visits, the enlarged parathyroid showed progressive shrinkage with eucalcemia and normalized PTH levels throughout 12 months of follow-up. Conclusions: Rarely, remission of PHPT may occur after ultrasound-guided-FNAB performed on a hyperfunctioning parathyroid lesion.

【 授权许可】

Unknown