Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age

Environment International

Itai Kloog¹  Iván Gutiérrez-Avila²  Diana C. Soria-Contreras³  Maayan Yitshak-Sade⁴  Marcela Tamayo-Ortiz⁴  María Luisa Pizano-Zárate⁵  Martha M. Téllez-Rojo⁵  Elena Colicino⁵  Allan C. Just⁵  Mike Z. He⁵  Robert O. Wright⁶  Alejandra Cantoral⁷  Andrea A. Baccarelli⁸ 

[1] Corresponding author at: Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, United States.;Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel;UMF 4, South Delegation of the Federal District, Mexican Social Security Institute (IMSS), Mexico City, Mexico;Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico;Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, United States;Department of Health, Universidad Iberoamericana, Mexico City, Mexico;Nutrition and Bioprogramming Coordination, National Institute of Perinatology, Mexico City, Mexico;Occupational Health Research Unit, Mexican Social Security Institute (IMSS), Mexico City, Mexico;

关键词: Air pollution;    Particulate matter;    Temperature;    Diabetes;    Glycated hemoglobin;    HbA1c;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Air pollution has been linked to obesity while higher ambient temperatures typically reduce metabolic demand in a compensatory manner. Both relationships may impact glucose metabolism, thus we examined the association between intermediate- and long-term exposure to fine particulate matter (PM2.5) and ambient temperature and glycated hemoglobin (HbA1c), a longer-term marker of glucose control. Methods: We assessed 3-month, 6-month, and 12-month average air pollution and ambient temperature at 1-km2 spatial resolution via satellite remote sensing models (2013–2019), and assessed HbA1c at four, six, and eight years postpartum in women enrolled in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort based in Mexico City. PM2.5 and ambient temperature were matched to participants’ addresses and confirmed by GPS tracker. Using linear mixed-effects models, we examined the association between 3-month, 6-month, and 12-month average PM2.5 and ambient temperature with repeated log-transformed HbA1c values. All models included a random intercept for each woman and were adjusted for calendar year, season, and individual-level confounders (age, marital status, smoking, alcohol consumption level, and education level). Results: We analyzed 1,265 HbA1c measurements of 484 women. Per 1 µg/m3 increase in 3-month and 6-month PM2.5, HbA1c levels increased by 0.28% (95% confidence interval (95 %CI): 0.14, 0.42%) and 0.28% (95 %CI: 0.04, 0.52%) respectively. No association was seen for 12-month average PM2.5. Per 1 °C increase in ambient temperature, HbA1c levels decreased by 0.63% (95 %CI: −1.06, −0.21%) and 0.61% (95 %CI: −1.08, −0.13%), while the 12-month average again is not associated with HbA1c. Conclusions: Intermediate-term exposure to PM2.5 and ambient temperature are associated with opposing changes in HbA1c levels, in this region of high PM2.5 and moderate temperature fluctuation. These effects, measurable in mid-adult life, may portend future risk of type 2 diabetes and possible heart disease.

【 授权许可】

Unknown