Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases

Cancers

RubenMercado Santos¹  WenCai Zhang¹  Cerena Moreno¹  Robert Burns¹ 

[1] Department of Cancer Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd, Orlando, FL 32827, USA;

关键词: succinate dehydrogenase;    cancer;    disease;    tricarboxylic acid cycle;    electron transport chain;    metabolism;   

DOI  :  10.3390/cancers12113237

来源: DOAJ

【 摘 要 】

Succinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. However, SDH mutation or dysfunction-induced succinate accumulation results in multiple cancers and non-cancer diseases. The mechanistic studies show that succinate activates hypoxia response and other signal pathways via binding to 2-oxoglutarate-dependent oxygenases and succinate receptors. Recently, the increasing knowledge of ribonucleic acid (RNA) networks, including non-coding RNAs, RNA editors, and RNA modifiers has expanded our understanding of the interplay between SDH and RNA networks in cancer and other diseases. Here, we summarize recent discoveries in the RNA networks and their connections to SDH. Additionally, we discuss current therapeutics targeting SDH in both pre-clinical and clinical trials. Thus, we propose a new model of SDH–RNA network interaction and bring promising RNA therapeutics against SDH-relevant cancer and other diseases.

【 授权许可】

Unknown