Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women

International Journal of Fertility and Sterility

Aliakbar Rasekhi¹  Ebrahim Hajizadeh¹  Azadeh Ghaheri¹  Reza Omani Samani² 

[1] Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institutefor Reproductive Biomedicine, ACECR, Tehran, Iran;

关键词: cluster analysis;    infertility;    fertilization;   

DOI  :  10.22074/ijfs.2018.5187

来源: DOAJ

【 摘 要 】

BackgroundWomen undergoing in vitro fertilization (IVF) cycles should successfully go through multiple pointsduring the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve livebirths. In this study, data from multiple cycles and multiple points during the IVF cycle are collected for each individual to model the effects of factors associated with success at different stages of IVF cycles in Iranian infertile women.Materials and MethodsThis historical cohort study includes 996 assisted reproductive technology (ART) cycles of 511 infertile women. Covariates considered in this study were women’s age, type of cycle (fresh or frozen embryo transfer), numberof embryos transferred and having polycystic ovarian syndrome during IVF cycles. Generalized estimating equations wereused for calculation of odds ratio (OR) and 95% confidence intervals (95% CI) of success at different stages during IVF cycles.Cluster-weighted generalized estimating equations (CWGEE) was also fitted to handle informative cluster size.ResultsAfter adjusting for potential confounders, it was seen that receiving frozen embryo transfer was associatedwith higher odds of success compared to receiving fresh embryo transfer (adj OR: 2.26, 95% CI: 1.66-3.07); however,cycles with fresh embryo transfer exhibited better results in clinical pregnancy compared to those receiving frozenembryo. Being in the age category of 38 to 40 was associated with lower odds of success compared to the referencecategory (

【 授权许可】

Unknown