Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits

Dentistry Journal

Daniele Botticelli¹  Karol Alí Apaza Alccayhuaman²  Vitor Ferreira Balan³  Samuel Porfirio Xavier³  Riccardo Favero⁴  Veronica Macchi⁴  Raffaele De Caro⁴ 

[1] ARDEC Academy, 47923 Rimini, Italy;Department of Oral Biology, Medical University of Vienna, 1090 Vienna, Austria;Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, Brazil;Dipartimento di Neuroscienze, Università di Padova, 35128 Padova, Italy;

关键词: animal study;    sinus floor elevation;    bone healing;    Schneiderian membrane;    histology;   

DOI  :  10.3390/dj10010002

来源: DOAJ

【 摘 要 】

Background: Experimental studies have shown a progressive thinning and perforations of the sinus mucosa associated with sharpened edges and the cutting projections of graft particles used simultaneously for maxillary sinus augmentation. Hence, the aim of the present study was to evaluate the damaging effects of two different bovine grafts on the sinus mucosa after sinus augmentation. Methods: Twenty New Zealand rabbits received a bilateral sinus lifting using, as fillers, two different types of deproteinized bovine bone in granules, one processed at low temperature (low-T group), and the other at high temperature (high-T group). Thinned mucosa sites (<40 µm) and perforations were evaluated in the sinus mucosa that were in contact with graft granules after 2 and 10 weeks, in ten animals per period. Results: After 2 weeks of healing, the number of thinned mucosa sites was 118 in the low-T group, and 149 in the high-T group (p = 0.191). At the 10-week assessment, the thinned sites increased to 237 and 195 sites, respectively. The numbers of sinus mucosa perforations after 2 weeks were eight and three in the low-T and high-T group, respectively. At the 10-week evaluation, the perforations increased to 19 in the low-T group, and to 14 in the high-T group. Conclusions: The contact with bovine xenografts yielded thinning and perforations of the sinus mucosa. Despite the differences in characteristics and dimensions, no differences were found between the two xenografts in the numbers of thinning mucosa sites and perforations. However, a trend of more events was found in the low-T compared to the high-T group.

【 授权许可】

Unknown