Perinatal Exposure to Phthalates: From Endocrine to Neurodevelopment Effects

International Journal of Molecular Sciences

Carlotta Plessi¹  Erica Passini²  Viola Trevisani²  Barbara Predieri³  Lorenzo Iughetti³  Laura Lucaccioni³  Beatrice Righi⁴ 

[1] Department of Medical and Surgical Sciences and NeuroSciences, Post Graduate School of Pediatric Surgery, University of Siena, 53100 Siena, Italy;Department of Medical and Surgical Sciences of the Mothers, Post Graduate School of Paediatrics, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy;Pediatric Unit, Department of Medical and Surgical Sciences of the Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy;Pediatric Unit, Ramazzini Hospital, 41012 Carpi, MO, Italy;

关键词: phthalates;    endocrine disrupting chemicals (EDCs);    prenatal exposure;    endocrine endpoints;    neurodevelopment;    newborn;   

DOI  :  10.3390/ijms22084063

来源: DOAJ

【 摘 要 】

Phthalates, as other endocrine disrupting chemicals (EDCs), may alter the homeostasis and the action of hormones and signaling molecules, causing adverse health outcomes. This is true especially for infants, who are both more exposed and sensitive to their effects. Phthalates are particularly harmful when the exposure occurs during certain critical temporal windows of the development, such as the prenatal and the early postnatal phases. Phthalates may also interfere with the neuroendocrine systems (e.g., thyroid hormone signaling or metabolism), causing disruption of neuronal differentiation and maturation, increasing the risk of behavioral and cognitive disorders (ADHD and autistic behaviors, reduced mental, psychomotor, and IQ development, and emotional problems). Despite more studies being needed to better understand the role of these substances, plenty of evidence suggests the impact of phthalates on the neuroendocrine system development and function. This review aims to update the knowledge on the neuroendocrine consequences of neonatal and perinatal exposure to phthalates.

【 授权许可】

Unknown