Convergent synthesis of the tetrasaccharide repeating unit of the cell wall lipopolysaccharide of Escherichia coli O40

Beilstein Journal of Organic Chemistry

Anup Kumar Misra¹  Abhijit Sau² 

[1] FAX: [phone];Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata-700054, India;

关键词: Escherichia coli;    glycosylation;    lipopolysaccharide;    O-antigen;    tetrasaccharide;   

DOI  :  10.3762/bjoc.8.230

来源: DOAJ

【 摘 要 】

A tetrasaccharide repeating unit corresponding to the cell-wall lipopolysaccharide of E. coli O40 was synthesized by using a convergent block glycosylation strategy. A disaccharide donor was coupled to a disaccharide acceptor by a stereoselective glycosylation. A 2-aminoethyl linker was chosen as the anomeric protecting group at the reducing end of the tetrasaccharide. All glycosylation steps are significantly high yielding and stereoselective.

【 授权许可】

Unknown