Association between Habitual Dietary Iron Intake and Glucose Metabolism in Individuals after Acute Pancreatitis

Nutrients

SakinaH. Bharmal¹  Xinye Li¹  Wandia Kimita¹  MaximS. Petrov¹  Juyeon Ko¹  David Cameron-Smith² 

[1] School of Medicine, University of Auckland, Auckland 1023, New Zealand;Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore 117609, Singapore;

关键词: dietary iron;    haem iron;    non-haem iron;    acute pancreatitis;    haemoglobin A1c;    fasting plasma glucose;   

DOI  :  10.3390/nu12113579

来源: DOAJ

【 摘 要 】

Dietary intake of iron is known to be associated with impaired glucose metabolism. However, its involvement in derangements of glucose metabolism after acute pancreatitis (AP) is not completely understood. The aim was to investigate the association between dietary iron intake and markers of glucose metabolism in individuals after an attack of AP. Fasting blood samples were collected to analyse markers of glucose metabolism (fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c)). The EPIC-Norfolk food frequency questionnaire was used to determine the habitual intake of dietary iron (total, haem, and non-haem). Multivariable linear regression analyses were conducted and six statistical models were built to adjust for covariates. A total of 109 individuals after AP were studied in a cross-sectional fashion. Total iron (β (95% confidence interval) = −0.19 (−0.35, −0.05); p = 0.01 in the most adjusted model) and non-haem iron (β (95% confidence interval) = −0.19 (−0.33, −0.04); p = 0.03 in the most adjusted model) were significantly associated with FPG, consistently in all adjusted model. Total iron and non-haem iron did not have consistent significant associations with HbA1c. Dietary haem iron intake was not associated with either FPG or HbA1c. Habitual intake of dietary iron is inversely associated with FPG in individuals after an attack of AP and may be involved in the pathogenesis of new-onset diabetes after pancreatitis. Prospective longitudinal studies are now warranted to unveil the specific mechanism underlying the involvement of dietary iron.

【 授权许可】

Unknown