Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis

International Journal of Molecular Sciences

Michela Campolo¹  Salvatore Cuzzocrea¹  Emanuela Esposito¹  Giovanna Calabrese¹  Alessia Filippone¹  Irene Paterniti¹  Alessio Ardizzone¹  Francesca Esposito²  Cristina Colarossi³  Dario Giuffrida³ 

[1] Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 98166 Messina, Italy;IOM Ricerca Srl, Via Penninazzo 11, 95029 Viagrande, Italy;Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy;

关键词: cancer;    miRNAs;    miR-19a;    tumor suppressors;    oncogene;    diagnostic and prognostic markers;   

DOI  :  10.3390/ijms22094697

来源: DOAJ

【 摘 要 】

Cancer is a multifactorial disease that affects millions of people every year and is one of the most common causes of death in the world. The high mortality rate is very often linked to late diagnosis; in fact, nowadays there are a lack of efficient and specific markers for the early diagnosis and prognosis of cancer. In recent years, the discovery of new diagnostic markers, including microRNAs (miRNAs), has been an important turning point for cancer research. miRNAs are small, endogenous, non-coding RNAs that regulate gene expression. Compelling evidence has showed that many miRNAs are aberrantly expressed in human carcinomas and can act with either tumor-promoting or tumor-suppressing functions. miR-19a is one of the most investigated miRNAs, whose dysregulated expression is involved in different types of tumors and has been potentially associated with the prognosis of cancer patients. The aim of this review is to investigate the role of miR-19a in cancer, highlighting its involvement in cell proliferation, cell growth, cell death, tissue invasion and migration, as well as in angiogenesis. On these bases, miR-19a could prove to be truly useful as a potential diagnostic, prognostic, and therapeutic marker.

【 授权许可】

Unknown