Reactions of Nitroxides, Part 17. Synthesis, Fungistatic and Bacteriostatic Activity of Novel Five- and Six-Membered Nitroxyl Selenoureas and Selenocarbamates

Molecules

Anna Kiełczewska¹  Katarzyna Jaszczuk¹  Jarosław Hupko¹  Maria Krawczyk¹  Jerzy Zakrzewski¹  Bogumiła Huras¹ 

[1] Łukasiewicz Research Network-Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warsaw, Poland;

关键词: organoselenium compounds;    selenoureas;    selenocarbamates;    fungistatic activity;    bacteriostatic activity;   

DOI  :  10.3390/molecules24132457

来源: DOAJ

【 摘 要 】

The reactions of 3-isoselenocyanato-2,2,5,5-tetramethylpyrrolidine-1-oxyl, 3-isoselenocyanatomethyl-2,2,5,5-tetramethyl-3-pyrrolidine-1-oxyl, and 4-isoselenocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl with selected amines and alcohols give the corresponding novel nitroxyl selenoureas and selenocarbamates, all bearing a nitroxyl moiety. Synthesized selenoureas and selenocarbamates show significant activity against pathogenic fungi and bacteria. In contrast to piperidine nitroxides, pyrrolidine, five-membered nitroxyl selenoureas and selenocarbamates show excellent antifungal and antibacterial activity against pathogenic fungi and bacteria, respectively.

【 授权许可】

Unknown