Pharmacoeconomic characteristics of ixabepilone (Ixempra) monotherapy in patients with locally advanced and metastatic breast cancer resistant to treatment with anthracyclines, taxanes and capecitabin

Современная онкология

A A Mosikyan¹  Yu E Balykina²  A A Kurilev²  A S Kolbin²  M A Proskurin³ 

[1] Saint Petersburg State University;I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation;Saint Petersburg State University;

关键词: ixabepilone;    metastatic breast cancer;    anthracyclines;    taxanes;    capecitabine;    resistant;    single agent;   

DOI  :  

来源: DOAJ

【 摘 要 】

This article represents data on economic evaluation of treatment with ixabepilone (Ixempra) as a single agent for patients with metastatic breast cancer with ineffective pretreatment with taxanes, anthracyclines and capecitabine. Two health technologies were evaluated: Ixabepilone as a single agent at the 1st day of a 21-day cycle of chemotherapy versus eribulin also as a single agent at the 1st and the 8th days of a 21-day cycle. Cost-effectiveness analysis is performed on the basis of published data and Markov modeling. As a result, ixabepilone as a single agent appeared to be economically reasonable as compared to eribulin as a single agent in case of ineffective pretreatment with taxanes, anthracyclines and capecitabine. Total expenditures for Ixabepilone strategy were 13.6% less than those for eribulin treatment. Furthermore, ixabepilone was found 16% more effective in terms of median progression-free survival, as compared to eribulin as a single agent. Sensitivity analysis has proved the results obtained in the main scenario. Price elasticity analysis revealed the equality of total expenditures on ixabepilone and eribulin treatment at a price of ixabepilone equal to 88 000 rubles per 45 mg vial and 30 298.87 rubles per 15 mg vial of ixabepilone.

【 授权许可】

Unknown