T Cells in Fish

Biology

Teruyuki Nakanishi¹  Yasuhiro Shibasaki¹  Yuta Matsuura¹ 

[1] Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa 252-0880, Japan;

关键词: T cells;    CD4;    CD8;    Thymus;    Cytotoxicity;   

DOI  :  10.3390/biology4040640

来源: DOAJ

【 摘 要 】

Cartilaginous and bony fish are the most primitive vertebrates with a thymus, and possess T cells equivalent to those in mammals. There are a number of studies in fish demonstrating that the thymus is the essential organ for development of T lymphocytes from early thymocyte progenitors to functionally competent T cells. A high number of T cells in the intestine and gills has been reported in several fish species. Involvement of CD4+ and CD8α+ T cells in allograft rejection and graft-versus-host reaction (GVHR) has been demonstrated using monoclonal antibodies. Conservation of CD4+ helper T cell functions among teleost fishes has been suggested in a number studies employing mixed leukocyte culture (MLC) and hapten/carrier effect. Alloantigen- and virus-specific cytotoxicity has also been demonstrated in ginbuna and rainbow trout. Furthermore, the important role of cell-mediated immunity rather than humoral immunity has been reported in the protection against intracellular bacterial infection. Recently, the direct antibacterial activity of CD8α+, CD4+ T-cells and sIgM+ cells in fish has been reported. In this review, we summarize the recent progress in T cell research focusing on the tissue distribution and function of fish T cells.

【 授权许可】

Unknown