A Role for the Action Observation Network in Apraxia After Stroke

Frontiers in Human Neuroscience

Dante Mantini¹  James Kolasinski²  Jane M. Riddoch³  Richard E. Passingham³  Elisabeth Rounis⁴  Zuo Zhang⁶  Gloria Pizzamiglio⁷ 

[1] Brain Imaging and Neural Dynamics Research Group, IRCCS San Camillo Hospital, Venice, Italy;Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom;Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom;Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;Research Centre for Motor Control and Neuroplasticity, KU Leuven, Leuven, Belgium;Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom;Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, London, United Kingdom;

关键词: apraxia;    voxel-based lesion-symptom mapping;    gesture production;    gesture recognition;    meaningless gesture imitation;    superior temporal sulcus;   

DOI  :  10.3389/fnhum.2019.00422

来源: DOAJ

【 摘 要 】

Limb apraxia is a syndrome often observed after stroke that affects the ability to perform skilled actions despite intact elementary motor and sensory systems. In a large cohort of unselected stroke patients with lesions to the left, right, and bilateral hemispheres, we used voxel-based lesion-symptom mapping (VLSM) on clinical CT head images to identify the neuroanatomical correlates of the impairment of performance in three tasks investigating praxis skills in patient populations. These included a meaningless gesture imitation task, a gesture production task involving pantomiming transitive and intransitive gestures, and a gesture recognition task involving recognition of these same categories of gestures. Neocortical lesions associated with poor performance in these tasks were all in the left hemisphere. They involved the pre-striate and medial temporal cortices, the superior temporal sulcus, inferior parietal area PGi, the superior longitudinal fasciculus underlying the primary motor cortex, and the uncinate fasciculus, subserving connections between temporal and frontal regions. No significant lesions were identified when language deficits, as indicated via a picture naming task, were controlled for. The implication of the superior temporal sulcus and the anatomically connected prestriate and inferior parietal regions challenges traditional models of the disorder. The network identified has been implicated in studies of action observation, which might share cognitive functions sub-serving praxis and language skills.

【 授权许可】

Unknown