Antiplatelet treatment and gastro-intestinal hemorrhage risk

Кардиоваскулярная терапия и профилактика

D. V. Duplyakov¹ 

[1] VAZ Medical Center, Togliatti;

关键词: antiplatelet treatment;    aspirin;    clopidogrel;    gastro-intestinal hemorrhage;   

DOI  :  

来源: DOAJ

【 摘 要 】

Ratio of atherothrombotic risk and risk of hemorrhage complications should be estimated before aspirin prescription as a component of cardiovascular event prevention. It is unlikely that there exists a daily aspirin dose, possessing antiplatelet efficacy, but without gastro-intestinal (GI) hemorrhage risk. Data of large-scale randomized trails have demonstrated the benefits of clopidogrel, with fewer adverse effects and better tolerability. According to CAPRIE trail results, clopidogrel should be prescribed to high-risk patients unable to take aspirin. It is recommended to use only minimal effective aspirin doses in combination with clopidogrel. The strategy of GI protection with proton pump inhibitors and/or H. pylori eradication for aspirin-taking patients at high risk of GI bleeding is widely discussed in literature. Up to now, there is little evidence supporting this strategy that is most important for life-long protection against atherothrombotic events.

【 授权许可】

Unknown