Association of Heavy Metals with Overall Mortality in a Taiwanese Population

Nutrients

Wen-Hsien Lee¹  Ying-Chih Chen¹  Ho-Ming Su¹  Chih-Wen Wang¹  Szu-Chia Chen¹  Yi-Hsueh Liu¹  Da-Wei Wu¹  Chao-Hung Kuo¹  Chun-Chi Tsai²  Wen-Yi Lin²  Chiu-Hui Li²  Chih-Hsing Hung³ 

[1] Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan;Health Management and Occupational Safety Health Center, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan;Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 812, Taiwan;

关键词: heavy metals;    mortality;    Taiwanese Population;    cadmium;    copper;    manganese;   

DOI  :  10.3390/nu13062070

来源: DOAJ

【 摘 要 】

Previous studies have shown links between heavy metals and many health issues. However, data on the association between heavy metals and mortality in the general population are still limited. Therefore, the aim of this study was to investigate the relationship between heavy metals and overall mortality in the general population. We enrolled 2497 participants (1001 males and 1496 females) living in southern Taiwan, and measured levels of seven heavy metals: lead (Pb) in blood and cadmium (Cd), nickel (Ni), copper (Cu), chromium (Cr), manganese (Mn) and arsenic (As) in urine. The median follow-up period was 41.8 (4–50) months, during which 40 (1.6%) patients died. Compared to the participants who survived, those who died had higher urine Cd, higher urine Cu and lower urine Mn levels. Multivariate analysis showed that high urine Cd (per 1 μg/L; hazard ratio [HR], 1.352; 95% confidence interval [CI], 1.089–1.680; p = 0.006), high urine Cu (per 1 μg/dL; HR, 1.350; 95% CI, 1.151–1.583; p < 0.001), and low urine Mn (per 1 μg/L; HR, 0.717; 95% CI, 0.557–0.923; p = 0.010) were associated with increased overall mortality. In conclusion, our results demonstrated that high levels of urine Cd and Cu and low urine Mn level were associated with increased overall mortality in the general population.

【 授权许可】

Unknown