Comparison of Post-Transplantation Lymphoproliferative Disorder Risk and Prognostic Factors between Kidney and Liver Transplant Recipients

Cancers

Beata Naumnik¹  Maciej Kosieradzki²  Krzysztof Zieniewicz³  Sławomir Nazarewski⁴  Leszek Pączek⁵  Rafał Staros⁵  Bartosz Foroncewicz⁵  Krzysztof Mucha⁵  Joanna Raszeja-Wyszomirska⁶  Bogna Ziarkiewicz-Wróblewska⁷ 

[1] 1st Department of Nephrology and Transplantation with Dialysis Unit, Medical University of Białystok, 15-540 Białystok, Poland;Department of General and Transplant Surgery, Medical University of Warsaw, 02-006 Warsaw, Poland;Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland;Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland;Department of Immunology, Transplantation and Internal Medicine, Medical University of Warsaw, 02-006 Warsaw, Poland;Liver and Internal Medicine Unit, Medical University of Warsaw, 02-097 Warsaw, Poland;University Clinical Center, Medical University of Warsaw, 02-091 Warsaw, Poland;

关键词: kidney transplantation;    liver transplantation;    post-transplant lymphoproliferative disorder;    solid organ transplantation;   

DOI  :  10.3390/cancers14081953

来源: DOAJ

【 摘 要 】

Post-transplantation lymphoproliferative disorder (PTLD) is a life-threatening complication of solid organ transplantation (SOT). Its development risk varies among organ graft recipients. In this study, retrospective data were analyzed to compare PTLD’s risk and prognostic factors between adult kidney and liver transplant recipients (KTRs and LTRs, respectively). Over 15 years, 2598 KTRs and 1378 LTRs were under observation at our center. Sixteen KTRs (0.62%) and twenty-three LTRs (1.67%) were diagnosed with PTLD. PTLD developed earlier in LTRs (p < 0.001), SOT patients > 45 years old (p = 0.002), and patients receiving tacrolimus (p < 0.001) or not receiving cyclosporin (p = 0.03) at diagnosis. Tacrolimus use, male sex, and age > 45 years old significantly affected the time of PTLD onset in KTRs (hazard ratio (HR) = 18.6, 7.9 and 5.2, respectively). Survival was longer in LTRs < 45 years old (p < 0.009). LTRs were more likely than KTRs to achieve complete remission (p = 0.039). Factors affecting PTLD development and outcome differ between KTRs and LTRs; thus, these populations should be separately evaluated in future studies.

【 授权许可】

Unknown