Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis

International Journal of Molecular Sciences

AntonioPellín Carcelén¹  Andrea Moreno-Manuel²  Silvia Calabuig-Fariñas²  Josep Marí-Alexandre³  Juan Gilabert-Estellés³  Cristina Agababyan³  Javier García-Oms³ 

[1] Department of Physiology, Universitat de València, 46010 València, Spain;Molecular Oncology Laboratory, Fundación para la Investigación del Hospital General Universitario de València, 46014, València, Spain;Research Laboratory in Biomarkers in Reproduction, Gynaecology and Obstetrics, Fundación Hospital General Universitario de Valencia, 46014 València, Spain;

关键词: oxidative stress;    mirnas;    endometriosis;    high-grade serous ovarian cancer;    endometriosis-associated ovarian cancer;    epithelial-to-mesenchymal transition;    chemoresistance;   

DOI  :  10.3390/ijms20215322

来源: DOAJ

【 摘 要 】

Ovarian cancer and endometriosis are two distinct gynaecological conditions that share many biological aspects incuding proliferation, invasion of surrounding tissue, inflammation, inhibition of apoptosis, deregulation of angiogenesis and the ability to spread at a distance. miRNAs are small non-coding RNAs (19−22 nt) that act as post-transcriptional modulators of gene expression and are involved in several of the aforementioned processes. In addition, a growing body of evidence supports the contribution of oxidative stress (OS) to these gynaecological diseases: increased peritoneal OS due to the decomposition of retrograde menstruation blood facilitates both endometriotic lesion development and fallopian tube malignant transformation leading to high-grade serous ovarian cancer (HGSOC). Furthermore, as HGSOC develops, increased OS levels are associated with chemoresistance. Finally, continued bleeding within ovarian endometrioma raises OS levels and contributes to the development of endometriosis-associated ovarian cancer (EAOC). Therefore, this review aims to address the need for a better understanding of the dialogue between miRNAs and oxidative stress in the pathophysiology of ovarian conditions: endometriosis, EAOC and HGSOC.

【 授权许可】

Unknown