Deficient sensorimotor gating induced by selective breeding in rats is improved by entopeduncular nucleus lesions

Neurobiology of Disease

Nino Polikashvili¹  Kerstin Schwabe²  Joachim K. Krauss³ 

[1] Corresponding author. Department of Neurosurgery, Medical University, MHH, Carl-Neuberg Str. 1, D-30625 Hannover, Germany.;Brain Research Institute, Department of Neuropharmacology, University of Bremen, P.O. Box 33 04 40, 28334 Bremen, Germany;Department of Neurosurgery, Medical University, MHH, Carl-Neuberg Str. 1, D-30625 Hannover, Germany;

关键词: Prepulse inhibition;    Startle;    Locomotor activity;    Globus pallidus internus;    Basal ganglia;    Neuropsychiatric disorders;   

DOI  :  

来源: DOAJ

【 摘 要 】

Deficient prepulse inhibition (PPI) of startle reflects disturbed sensorimotor gating found in certain neuropsychiatric disorders, such as Tourette's syndrome, ADHD, Huntington's and schizophrenia. We here tested, whether lesions of the entopeduncular nucleus (EPN) would improve a PPI-deficit induced by selective breeding. Rats with breeding induced high and low expression of PPI were stereotaxically microinjected with ibotenate (0.2 μg in 0.3 μl phosphate buffered saline) or vehicle into the EPN and two weeks later tested for PPI of the acoustic startle response (ASR) and motor activity. Lesions of the EPN counteracted the breeding-induced PPI-deficit and reduced ASR in the PPI low group without affecting their motor activity. In the PPI high group EPN lesions did not affect PPI, ASR, and motor activity. This work indicates an important role of the EPN in the modulation of sensorimotor gating. Additionally, PPI low rats may provide a non-pharmacological model that can be used to develop new therapeutic strategies for neuropsychiatric disorders.

【 授权许可】

Unknown