Metabolically Unhealthy Phenotype: A Key Factor in Determining “Pediatric” Frailty

Pediatric Reports

Gloria Pelizzo¹  Annalisa De Silvestri¹  Hellas Cena²  Gianvincenzo Zuccotti³  Valeria Calcaterra⁴  Gianni Bonalumi⁵  Annamaria Ruggieri⁵ 

[1] Clinical Epidemiology & Biometry, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy;Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy;Pediatric Unit, “V. Buzzi” Children’s Hospital, 20154 Milano, Italy;Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy;Vascular Surgery Unit, Istituto di Cura Città di Pavia, 27100 Pavia, Italy;

关键词: frailty;    metabolic syndrome;    obesity;    undernutrition;    children;    age;   

DOI  :  10.3390/pediatric13030042

来源: DOAJ

【 摘 要 】

Frailty (FI) and metabolic syndrome (MS) are each associated with adverse health outcomes. A relationship between FI and MS has previously been described in adults. We considered the prevalence of a metabolically unhealthy phenotype (MUP) in malnourished children with neurological impairment and in subjects with obesity in comparison to a group of elderly individuals at risk of FI, and we did so in order to define the potential similarities that may underline the risk of FI in specific children. We considered 50 undernourished (defined as having a body mass index of BMI ≤ 2, standard deviation score, SDS, according to World Health Organization) disabled children; 50 children with obesity (BMI ≥ 2 SDS); 50 children who were a normal weight (−1 SDS ≤ BMI ≤ +1 SDS); 21 patients who were >75 years old. MUP was defined as the presence of at least one of the following risk factors: hypertension, hyperglycemia or diabetes, hypercholesterolemia, and hypertriglyceridemia. In children with a disability and obesity, a higher prevalence (p < 0.001) and risk (disability OR 54.88, obesity OR 13.37) of MUP was noted compared to children of a normal weight. Compared to elderly patients, the prevalence of MUP did not differ in disabled children. On the contrary, MUP was lower in children with obesity (p < 0.001) and in pediatric subjects of a normal weight (p < 0.01). MS might play a key role in “pediatric” frailty. The extremities of the aging process and malnutrition are likely key factors in the development of FI. A multidisciplinary approach to FI may represent an important milestone for pediatric care.

【 授权许可】

Unknown