Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells

Uspehi Molekulârnoj Onkologii

O. E. Andreeva¹  A. M. Scherbakov¹  M. V. Gudkova¹  E. I. Mikhaevich¹  Yu. Yu. Shchegolev¹  M. A. Krasil’nikov¹  D. V. Sorokin² 

[1] Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia;НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России;

关键词: exosomes;    hormonal resistance;    micrornas;    estrogen receptor erα;   

DOI  :  10.17650/2313-805X-2020-7-3-58-62

来源: DOAJ

【 摘 要 】

The most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs.Previously we have revealed the effect of the transferring of the hormonal resistance from the resistant to the sensitive cells under in vitro cell co-cultivation, and demonstrated exosomes involvement in this process. Here we have shown that the exosomes of the resistant cells caused the marked inhibition of the estrogen signaling in the recipient cells, and identified microRNAs – ERα suppressors that overexpressed in the resistant exosomes.Taken together, the results obtained demonstrate the important role of the estrogen signaling suppression in the exosome-induced transferring of the hormonal resistance, and revealed the involvement of the exosomal microRNA in the ERα down-regulation.

【 授权许可】

Unknown