Colonic Cancer and Acromegaly

Frontiers in Endocrinology

Ashley B. Grossman¹  Dorota Dworakowska³ 

[1] Barts and the London School of Medicine, Centre for Endocrinology, William Harvey Institute, London, United Kingdom;Department of Hypertension and Diabetes, Medical University of Gdansk, Gdansk, Poland;Endocard LTD, London, United Kingdom;Guys Richard Dimbleby Department of Cancer Research, King's College London, London, United Kingdom;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom;

关键词: colon;    cancer;    acromegaly;    colonoscopy;    screening;   

DOI  :  10.3389/fendo.2019.00390

来源: DOAJ

【 摘 要 】

Acromegaly results in a significantly increased morbidity and mortality due to cardiovascular and respiratory complications, as well as malignancies arising mainly from the colon. Furthermore, an increased lifetime risk of malignant transformation of pre-malignant colonic lesions relates to a worse overall prognosis from colorectal cancer, which is currently considered a major disease-related complication. In this review we provide some insight into colonic changes in this condition, summarize current knowledge and evidence on the use of colonoscopic screening in patients with acromegaly, and suggest a recommended screening protocol.

【 授权许可】

Unknown