Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology

Micromachines

Shen-Fu Steve Hsu¹  Kai-Yuan Tang¹  Ta-Jen Yen²  Shih-Ting Huang³  Yen-Shuo Lin⁴  Da-Jeng Yao⁴ 

[1] ACE BIOTEK Co., Ltd., Hsinchu 30261, Taiwan;Department of Material Science Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan;Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan;Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu 30013, Taiwan;

关键词: terahertz;    metamaterials;    microfluidics;    sensitivity enhancement;    probiotic;   

DOI  :  10.3390/mi13060904

来源: DOAJ

【 摘 要 】

Terahertz (THz) radiation has attracted wide attention in recent years due to its non-destructive properties and ability to sense molecular structures. In applications combining terahertz radiation with metamaterial technology, the interaction between the terahertz radiation and the metamaterials causes resonance reactions; different analytes have different resonance performances in the frequency domain. In addition, a microfluidic system is able to provide low volume reagents for detection, reduce noise from the environment, and concentrate the sample on the detection area. Through simulation, a cruciform metamaterial pattern was designed; the proportion, periodicity, and width of the metamaterial were adjusted to improve the sensing capability of the chip. In the experiments, the sensing capabilities of Type A, B, and C chips were compared. The Type C chip had the most significant resonant effect; its maximum shift could be increased to 89 GHz. In the probiotic experiment, the cruciform chip could have a 0.72 GHz shift at a concentration of 0.025 mg/50 μL, confirming that terahertz radiation combined with a metamaterial microfluidic chip can perform low-concentration detection.

【 授权许可】

Unknown