Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation

International Journal of Molecular Sciences

Stefan Kippenberger¹  Nadja Zöller¹  August Bernd¹  Eva Juengel²  Roman A. Blaheta²  Felix K.-H. Chun²  Sebastian Maxeiner²  Wajdi Kassabra²  Aicha Benchellal²  Jochen Rutz² 

[1] Department of Dermatology, Venereology, and Allergology, Goethe-University, 60590 Frankfurt am Main, Germany;Department of Urology, Goethe-University, 60590 Frankfurt am Main, Germany;

关键词: curcumin;    light irradiation;    prostate cancer;    growth;    proliferation;    metastasis;   

DOI  :  10.3390/ijms22189966

来源: DOAJ

【 摘 要 】

Although anti-cancer properties of the natural compound curcumin have been reported, low absorption and rapid metabolisation limit clinical use. The present study investigated whether irradiation with visible light may enhance the inhibitory effects of low-dosed curcumin on prostate cancer cell growth, proliferation, and metastasis in vitro. DU145 and PC3 cells were incubated with low-dosed curcumin (0.1–0.4 µg/mL) and subsequently irradiated with 1.65 J/cm² visible light for 5 min. Controls remained untreated and/or non-irradiated. Cell growth, proliferation, apoptosis, adhesion, and chemotaxis were evaluated, as was cell cycle regulating protein expression (CDK, Cyclins), and integrins of the α- and β-family. Curcumin or light alone did not cause any significant effects on tumor growth, proliferation, or metastasis. However, curcumin combined with light irradiation significantly suppressed tumor growth, adhesion, and migration. Phosphorylation of CDK1 decreased and expression of the counter-receptors cyclin A and B was diminished. Integrin α and β subtypes were also reduced, compared to controls. Irradiation distinctly enhances the anti-tumor potential of curcumin in vitro and may hold promise in treating prostate cancer.

【 授权许可】

Unknown