Canine visceral leishmaniasis in Araçatuba, state of São Paulo, Brazil, and its relationship with characteristics of dogs and their owners: a cross-sectional and spatial analysis using a geostatistical approach

BMC Veterinary Research

Lucas Xavier Bonfietti¹  Rafael Silva Cipriano²  Graziela Cândido Diniz Cardoso²  Francisco Chiaravalloti-Neto³  Caris Maroni Nunes⁴  Marta Blangiardo⁵  Roberto Mitsuyoshi Hiramoto⁶  José Eduardo Tolezano⁶  Cláudia Torres Codeço⁷  Patricia Marques Moralejo Bermudi⁸  Danielle Nunes Carneiro Castro Costa⁸  Lilian Aparecida Colebrusco Rodas⁹ 

[1] Cento de Laboratório Regional I Araçatuba, Instituto Adolfo Lutz;Centro de Controle de Zoonozes;Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo (USP);Laboratório de Bioquímica e Biologia Molecular, Departamento de Apoio Produção e Saúde Animal, Faculdade de Medicina Veterinária de Araçatuba, Unesp;MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College;Núcleo de Parasitoses Sistêmicas, Instituto Adolfo Lutz;Programa de Computação Científica, Fundação Oswaldo Cruz;Programa de Pós-graduação em Saúde Pública, Faculdade de Saúde Pública, USP;Serviço Regional 9, Superintendência de Controle de Endemias;

关键词: Visceral leishmaniasis;    Dogs;    Cross-sectional study;    Geostatistical analysis;    Brazil;   

DOI  :  10.1186/s12917-018-1550-9

来源: DOAJ

【 摘 要 】

Abstract Background The incidence of visceral leishmaniasis (VL), one of the most important neglected diseases worldwide, is increasing in Brazil. The objectives of this study were to determine the canine VL (CanL) seroprevalence in an urban area of Araçatuba municipality and to evaluate its relationship with the characteristics of dogs and their owners. Results The CanL seroprevalence in the study area was 0.081 (95% credible interval [CI]: 0.068–0.096). The following covariates/categories were positively associated with the occurrence of a seropositive dog: more than 10 dogs that had lived in the house (odds ratio [OR] = 2.36; 95% CI: 1.03–5.43) (baseline: 0–10 dogs); house with dogs that previously died of VL (OR = 4.85; 95% CI: 2.65–8.86) or died of causes other than old age (OR = 2.26; 95% CI: 1.12–4.46) (baseline: natural or no deaths); dogs that spent the day in a sheltered backyard (OR = 2.14; 95% CI: 1.05–4.40); dogs that spent the day in an unsheltered backyard or the street (OR = 2.67; 95% CI: 1.28–5.57) (baseline: inside home). Spatial dependence among observations occurred within about 45.7 m. Conclusions The number of dogs that had lived in the house, previous deaths by VL or other cause, and the place the dog stayed during the day were associated with the occurrence of a VL seropositive dog. The short-distance spatial dependence could be related to the vector characteristics, producing a local neighbourhood VL transmission pattern. The geostatistical approach in a Bayesian context using integrated nested Laplace approximation (INLA) allowed to identify the covariates associated with VL, including its spatially dependent transmission pattern.

【 授权许可】

Unknown