Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment

Annals of Hepatology

Pramod Kumar¹  Sahaj Rathi²  Virendra Singh²  Yogesh Kumar Chawla²  Sunil Taneja³  Radha Krishan Dhiman⁴  Ajay Duseja⁴ 

[1] Department of Hepatology, Postgraduate Institute of Medical Education &Research, Chandigarh, India;Correspondence and reprint request:;;Department of Hepatology, Postgraduate Institute of Medical Education &

关键词: Drug induced liver injury;    Hepatotoxin;    Liver failure;    Liver transplantation;    Hepatic encephalopathy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepa-totoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF. Antibiotics are the most common cause of idiosyncratic DILI as well as DILI induced ALF. Etodolac is a selective cycloxygenase- 2 (COX -2) inhibitor non-steroidal anti-inflammatory drug used as an analgesic and anti-inflammatory in musculoskeletal diseases. Severe liver impairment is extremely rare. Till date, only 3 cases of ALF related to etodolac have been reported in the literature. Here we report two cases with a unique presentation of ALF occurring due to DILI caused by etodolac, as diagnosed by Roussel Uclaf Causality Assessment Method (RUCAM).

【 授权许可】

Unknown