The Role of Lung Colonization in Connective Tissue Disease-Associated Interstitial Lung Disease

Microorganisms

Roberta Di Rosa¹  Bruno Lagan๠ Simonetta Salemi¹  Alberto Ricci²  Francesco Scarso²  Michela D’Ascanio²  Dario Pizzirusso²  Marta Innammorato²  Raffaele Sglavo²  Alessandra Pagliuca²  Morgana Vermi² 

[1] U.O.C. Medicina Interna, Dipartimento Medicina Clinica e Molecolare, Sapienza Università di Roma, A.O.U. Sant’Andrea, 00189 Rome, Italy;U.O.C. Pneumologia, DipartimentoMedicina Clinica e Molecolare, Sapienza Università di Roma, A.O.U. Sant’Andrea, 00189 Rome, Italy;

关键词: interstitial lung diseases;    connective tissue diseases;    autoimmune disease;    microbiota;    pulmonary fibrosis;    lung function tests;   

DOI  :  10.3390/microorganisms9050932

来源: DOAJ

【 摘 要 】

Connective tissue diseases (CTDs) may frequently manifest with interstitial lung disease (ILD), which may severely impair quality and expectation of life. CTD-ILD generally has a chronic clinical course, with possible acute exacerbations. Although several lines of evidence indicate a relevant role of infections in the acute exacerbations of CTD-ILD, little information is available regarding the prevalence of infections in chronic CTD-ILD and their possible role in the clinical course. The aim of the present retrospective study was the identification of lung microbial colonization in broncho-alveolar lavage from patients affected by stable CTD-ILD with radiologically defined lung involvement. We demonstrated that 22.7% of patients with CTD-ILD display microbial colonization by Pseudomonas aeruginosa, Haemophilus influenzae, and non-tuberculous mycobacteria. Moreover, these patients display a major radiologic lung involvement, with higher impairment in lung function tests confirmed in a multivariate logistic regression analysis. Overall, the present study provides new information on lung colonization during CTD-ILD and its possible relationship with lung disease progression and severity.

【 授权许可】

Unknown