Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow

Advanced Science

Anastasia Rakow¹  Carsten Perka¹  Katrin Huesker²  Remi Tucoulou³  Marine Cotte³  Janosch Schoon⁴  Melanie J. Ort⁴  Dorit Jacobi⁴  Georg N. Duda⁴  Sven Geissler⁴  Simon Reinke⁴  Annika Winter⁵  Uwe Marx⁵  Bernhard Hesse⁶  Adrien Lagrange⁶ 

[1] Berlin Institute of Health Center for Regenerative Therapies Berlin Institute of Health Berlin 10178 Germany;Endocrinology and Immunology Department Institute for Medical Diagnostics Berlin 12247 Germany;European Synchrotron Radiation Facility Grenoble 38000 France;Julius Wolff Institute Charité – Universitätsmedizin Berlin Berlin 13353 Germany;TissUse GmbH Berlin 13347 Germany;Xploraytion GmbH Berlin 10625 Germany;

关键词: arthroplasty;    bone marrow;    metal exposure;    nanoparticles;    synchrotron radiation;   

DOI  :  10.1002/advs.202000412

来源: DOAJ

【 摘 要 】

Abstract Metallic implants are frequently used in medicine to support and replace degenerated tissues. Implant loosening due to particle exposure remains a major cause for revision arthroplasty. The exact role of metal debris in sterile peri‐implant inflammation is controversial, as it remains unclear whether and how metals chemically alter and potentially accumulate behind an insulating peri‐implant membrane, in the adjacent bone and bone marrow (BM). An intensively focused and bright synchrotron X‐ray beam allows for spatially resolving the multi‐elemental composition of peri‐implant tissues from patients undergoing revision surgery. In peri‐implant BM, particulate cobalt (Co) is exclusively co‐localized with chromium (Cr), non‐particulate Cr accumulates in the BM matrix. Particles consisting of Co and Cr contain less Co than bulk alloy, which indicates a pronounced dissolution capacity. Particulate titanium (Ti) is abundant in the BM and analyzed Ti nanoparticles predominantly consist of titanium dioxide in the anatase crystal phase. Co and Cr but not Ti integrate into peri‐implant bone trabeculae. The characteristic of Cr to accumulate in the intertrabecular matrix and trabecular bone is reproducible in a human 3D in vitro model. This study illustrates the importance of updating the view on long‐term consequences of biomaterial usage and reveals toxicokinetics within highly sensitive organs.

【 授权许可】

Unknown