Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting

International Journal of Molecular Sciences

Tejeshwar Jain¹  Abhi C. Are¹  Utpreksha Vaish¹  Vikas Dudeja¹ 

[1] Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA;

关键词: pancreatic ductal adenocarcinoma;    pancreatic cancer;    cancer-associated fibroblasts;    myCAF;    iCAF;    apCAF;   

DOI  :  10.3390/ijms222413408

来源: DOAJ

【 摘 要 】

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related morbidity and mortality in the western world, with limited therapeutic strategies and dismal long-term survival. Cancer-associated fibroblasts (CAFs) are key components of the pancreatic tumor microenvironment, maintaining the extracellular matrix, while also being involved in intricate crosstalk with cancer cells and infiltrating immunocytes. Therefore, they are potential targets for developing therapeutic strategies against PDAC. However, recent studies have demonstrated significant heterogeneity in CAFs with respect to their origins, spatial distribution, and functional phenotypes within the PDAC tumor microenvironment. Therefore, it is imperative to understand and delineate this heterogeneity prior to targeting CAFs for PDAC therapy.

【 授权许可】

Unknown