Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

Arthritis Research & Therapy

Yujie Liang¹  Xiao Xu¹  Daping Wang¹  Li Duan¹  Caining Wen¹  Limei Xu¹ 

[1] Department of Orthopedics, Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University;

关键词: IGF-1;    Cartilage repair;    Chondrocytes;    Osteoarthritis;   

DOI  :  10.1186/s13075-021-02662-0

来源: DOAJ

【 摘 要 】

Abstract Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy.

【 授权许可】

Unknown