Deciphering New Players in the Neurogenic Adult Hippocampal Niche

Frontiers in Cell and Developmental Biology

Gustavo Paratcha¹  Antonela Bonafina¹  Fernanda Ledda² 

[1] División de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencias, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina;Fundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina;

关键词: neural stem cells;    adult hippocampal neurogenesis;    niche signals;    adult born granule cells;    granule cell integration;   

DOI  :  10.3389/fcell.2020.00548

来源: DOAJ

【 摘 要 】

In the mammalian adult hippocampus, new neurons are continuously generated throughout life in the subgranular zone of the dentate gyrus. Increasing evidence point out the contribution of adult-born hippocampal granule cells (GCs) to cognitive processes such as learning and memory, indicating the relevance of understanding the molecular mechanisms that control the development of these new neurons in the preexisting hippocampal circuits. Cell proliferation and functional integration of adult-born GCs is a process highly regulated by different intrinsic and extrinsic factors. In this review, we discuss recent advances related with cellular components and extrinsic signals of the hippocampal neurogenic niche that support and modulate neurogenesis under physiological conditions.

【 授权许可】

Unknown