High tumor-associated macrophages infiltration is associated with poor prognosis and may contribute to the phenomenon of epithelial–mesenchymal transition in gastric cancer

OncoTargets and Therapy

关键词: gastric cancer;    tumor-associated macrophages;    epithelial-mesenchymal transition;    transforming growth factor-β1;    prognosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Yan Yan,1 Jia Zhang,1 Jun-Hai Li,2 Xu Liu,1 Ji-Zhao Wang,1 Hang-Ying Qu,3 Jian-Sheng Wang,1,* Xiao-Yi Duan4,*1The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 2The Department of Oncological Surgery, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang, 3The Department of Oncological Surgery, Shaanxi University of Chinese Medicine, Xianyang, 4Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workBackground: Recent studies show that epithelial–mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) contribute to the progression and poor prognosis of carcinoma through multiple mechanisms. Both inflammation and changing of epithelium have a close relationship with tumorigenesis of gastric cancer. However, the relevance between EMT and TAMs is still unclear in gastric cancer and needs more scientific research. This study is designed to explore the relationship between EMT and TAMs in gastric cancer. Materials and methods: Immunohistochemistry was used to detect the expression of EMT-related proteins and TAM markers in cancer tissues and normal gastric tissues. Results: High levels of EMT and TAMs infiltration are related to aggressive features and independent prognostic factors in gastric cancer, respectively. In addition, expression of the two indicators is associated with expression of transforming growth factor-β1 (TGF-β1). Infiltration of TAMs is also associated with EMT-related marker in gastric cancer. Conclusion: Our results suggest that high levels of EMT and TAMs infiltration are related to aggressive features and independent prognostic factors in gastric cancer, respectively. A correlation was found between EMT- and TAM-related indicators, which may be associated with TGF-β signaling pathway. The level of TAMs infiltration plays an important role in gastric cancer, the markers of which can be used as prognostic indicators.Keywords: gastric cancer, prognosis, tumor-associated macrophages, E-cadherin, TGF-β1

【 授权许可】

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